Multiple sclerosis (MS) is a complicated disease characterized by heterogeneous pathology that varies across individuals. Accurate\r\nidentification and quantification of pathological changes may facilitate a better understanding of disease pathogenesis and\r\nprogression and help identify novel therapies for MS patients. Texture analysis evaluates interpixel relationships that generate\r\ncharacteristic organizational patterns in an image, many of which are beyond the ability of visual perception. Given its promise\r\ndetecting subtle structural alterations texture analysis may be an attractive means to evaluate disease activity and evolution. It\r\nmay also become a new tool to assess therapeutic efficacy if technique issues are resolved and pathological correlates are further\r\nconfirmed. This paper describes the concept, strategies, and considerations of MRI texture analysis; summarizes applications of\r\ntexture analysis in MS as a measure of tissue integrity and its clinical relevance; then discusses potentially future directions of\r\ntexture analysis in MS.
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